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Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a ne... PDF available through Get Fulltext Research

Fujita, Masaaki Zhu, Kan Fujita, Chitose K Zhao, Min Lam, Kit S Kurth, Mark J Takada, Yoko K Takada, Yoshikazu

Published in The Journal of biological chemistry

Integrins are activated by signaling from inside the cell (inside-out signaling) through global conformational changes of integrins. We recently discovered that fractalkine activates integrins in the absence of CX3CR1 through the direct binding of fractalkine to a ligand-binding site in the integrin headpiece (site 2) that is distinct from the clas...

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