Downregulation of PTEN at corneal wound sites accelerates wound healing through increased cell migration.
Published in Investigative ophthalmology & visual science
The PI3K/Akt pathway is required for cell polarization and migration, whereas the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has inhibitory effects on the PI3K/Akt pathway. The authors therefore hypothesized that wounding would downregulate PTEN and that this downregulation would enhance wound healing. In human corneal epithel...
