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Downregulation of PTEN at corneal wound sites accelerates wound healing through increased cell migration.

Cao, Lin Graue-Hernandez, Enrique O Tran, Vu Reid, Brian Pu, Jin Mannis, Mark J Zhao, Min

Published in Investigative ophthalmology & visual science

The PI3K/Akt pathway is required for cell polarization and migration, whereas the phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has inhibitory effects on the PI3K/Akt pathway. The authors therefore hypothesized that wounding would downregulate PTEN and that this downregulation would enhance wound healing. In human corneal epithel...

Acanthamoeba migration in an electric field.

Rudell, Jc Gao, J Yao-Hui Sun Yao-Hui Sun Chodosh, J Schwab, I Min Zhao

Published in Investigative Ophthalmology & Visual Science

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