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E-cadherin plays an essential role in collective directional migration of large epithelial sheets

Li, Li Hartley, Robert Reiss, Bjoern Sun, Yaohui Pu, Jin Wu, Dan Lin, Francis Hoang, Trung Yamada, Soichiro Jiang, Jianxin ...

Published in Cellular and Molecular Life Sciences

In wound healing and development, large epithelial sheets migrate collectively, in defined directions, and maintain tight cell–cell adhesion. This type of movement ensures an essential function of epithelia, a barrier, which is lost when cells lose connection and move in isolation. Unless wounded, epithelial sheets in cultures normally do not have ...

GSK-3β is essential for physiological electric field-directed Golgi polarization and optimal electrotaxis PDF available through Get Fulltext Research

Cao, Lin Pu, Jin Zhao, Min

Published in Cellular and Molecular Life Sciences

Endogenous electrical fields (EFs) at corneal and skin wounds send a powerful signal that directs cell migration during wound healing. This signal therefore may serve as a fundamental regulator directing cell polarization and migration. Very little is known of the intracellular and molecular mechanisms that mediate EF-induced cell polarization and ...

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