Ion-selective self-referencing probes for measuring specific ion flux
Published in Communicative & Integrative Biology
PI3K mediated electrotaxis of embryonic and adult neural progenitor cells in the presence of growth factors.
Published in Experimental neurology
Correct guidance of the migration of neural progenitor cells (NPCs) is essential for the development and repair of the central nervous system (CNS). Electric field (EF)-guided migration, electrotaxis, has been observed in many cell types. We report here that, in applied EFs of physiological magnitude, embryonic and adult NPCs show marked electrotax...
Chloride channels and transporters in human corneal epithelium.
Published in Experimental Eye Research
Transport of water and electrolytes is critical for corneal clarity. Recent studies indicate another important function of transport of ions and electrolytes - establishing wound electric fields that guide cell migration. We found chloride (Cl(-)) flux is a major component of the corneal wound electric current. In order to elucidate the mechanisms ...
Chapter 93 Electrical activation of wound healing pathways. Wound Healing Society Yearbook Section 11: Devices (Section ...
Electrical fields in wound healing-An overriding signal that directs cell migration.
Published in Seminars in cell & developmental biology
Injury that disrupts an epithelial layer instantaneously generates endogenous electric fields (EFs), which were detected at human skin wounds over 150 years ago. Recent researches combining molecular, genetic and imaging techniques have provided significant insights into cellular and molecular responses to this "unconventional" signal. One unexpect...
Modulating endogenous electric currents in human corneal wounds—a novel approach of bioelectric stimulation without elec...
Published in Cataract and Cornea Journal of the Egyptian Society of Cataract and Corneal Diseases
Polarizing intestinal epithelial cells electrically through Ror2.
Published in Journal of Cell Science
The apicobasal polarity of enterocytes determines where the brush border membrane (apical membrane) will form, but how this apical membrane faces the lumen is not well understood. The electrical signal across the epithelium could serve as a coordinating cue, orienting and polarizing enterocytes. Here, we show that applying a physiological electric ...
A time-lapse and quantitative modelling analysis of neural stem cell motion in the absence of directional cues and in el...
Published in Journal of Neuroscience Research
Neural stem cell (NSC) migration is an important component of their developmental function and therapeutic potential. Understanding their mode of migration and their response to guidance cues can contribute to improved therapies for CNS repair, in which appropriate homing to sites of injury is essential. Using time-lapse imaging, we have analyzed t...
Different roles of membrane potentials in electrotaxis and chemotaxis of dictyostelium cells.
Published in Eukaryotic Cell
Many types of cells migrate directionally in direct current (DC) electric fields (EFs), a phenomenon termed galvanotaxis or electrotaxis. The directional sensing mechanisms responsible for this response to EFs, however, remain unknown. Exposing cells to an EF causes changes in plasma membrane potentials (V(m)). Exploiting the ability of Dictyosteli...
A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing.
Published in Advances in Wound Care
