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News 56 Publications 12 Members

Diabetic cornea wounds produce significantly weaker electric signals that may contribute to impaired healing.

Shen, Yunyun Pfluger, Trisha Ferreira, Fernando Liang, Jiebing Navedo, Manuel F Zeng, Qunli Reid, Brian Zhao, Min

Published in Scientific reports

Wounds naturally produce electric signals which serve as powerful cues that stimulate and guide cell migration during wound healing. In diabetic patients, impaired wound healing is one of the most challenging complications in diabetes management. A fundamental gap in knowledge is whether diabetic wounds have abnormal electric signaling. Here we use...

KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis.

Nakajima, Ken-Ichi Zhu, Kan Sun, Yao-Hui Hegyi, Bence Zeng, Qunli Murphy, Christopher J Small, J Victor Chen-Izu, Ye Izumiya, Yoshihiro Penninger, Josef M ...

Published in Nature communications

Weak electric fields guide cell migration, known as galvanotaxis/electrotaxis. The sensor(s) cells use to detect the fields remain elusive. Here we perform a large-scale screen using an RNAi library targeting ion transporters in human cells. We identify 18 genes that show either defective or increased galvanotaxis after knockdown. Knockdown of the ...

Proinflammatory secreted phospholipase A2 type IIA (sPLA-IIA) induces integrin activation through direct binding to a ne...

Fujita, Masaaki Zhu, Kan Fujita, Chitose K Zhao, Min Lam, Kit S Kurth, Mark J Takada, Yoko K Takada, Yoshikazu

Published in The Journal of biological chemistry

Integrins are activated by signaling from inside the cell (inside-out signaling) through global conformational changes of integrins. We recently discovered that fractalkine activates integrins in the absence of CX3CR1 through the direct binding of fractalkine to a ligand-binding site in the integrin headpiece (site 2) that is distinct from the clas...

A large scale screen reveals genes that mediate electrotaxis in Dictyostelium discoideum

Gao, R Zhao, S Jiang, X Sun, S Zhao, S Gao, J Borleis, J Willard, S Tang, M Cai, H ...

Published in Science Signaling

ElectroTaxis-on-a-Chip (ETC): an integrated quantitative high-throughput screening platform for electrical field-directe...

Zhao, Siwei Kan Zhu Yan Zhang Zhu, Zijie Xu, Zhengping Min Zhao Pan, Tingrui

Published in Lab on a Chip

3D Arrays for high throughput assay of cell migration and electrotaxis

Zhao, Sanjun Gao, Runchi Devreotes, Peter N. Mogilner, Alex Min Zhao

Published in Cell Biology International

E-cadherin plays an essential role in collective directional migration of large epithelial sheets

Li, Li Hartley, Robert Reiss, Bjoern Sun, Yaohui Pu, Jin Wu, Dan Lin, Francis Hoang, Trung Yamada, Soichiro Jiang, Jianxin ...

Published in Cellular and Molecular Life Sciences

In wound healing and development, large epithelial sheets migrate collectively, in defined directions, and maintain tight cell–cell adhesion. This type of movement ensures an essential function of epithelia, a barrier, which is lost when cells lose connection and move in isolation. Unless wounded, epithelial sheets in cultures normally do not have ...

A Molecular Link Between Interleukin 22 and Intestinal Mucosal Wound Healing Advances in Wound Care

Sun, X Chalmers, L Fu, X Min Zhao

Directing migration of endothelial progenitor cells with applied DC electric fields.

Zhao, Zhiqiang Qin, Lu Reid, Brian Pu, Jin Hara, Takahiko Zhao, Min

Published in Stem cell research

Naturally-occurring, endogenous electric fields (EFs) have been detected at skin wounds, damaged tissue sites and vasculature. Applied EFs guide migration of many types of cells, including endothelial cells to migrate directionally. Homing of endothelial progenitor cells (EPCs) to an injury site is important for repair of vasculature and also for a...

Electric fields guide migration of epidermal stem cells and promote skin wound healing.

Li, Li Gu, Wei Du, Juan Reid, Brian Deng, Xianjian Liu, Zhidai Zong, Zhaowen Wang, Haiyan Yao, Bo Yang, Ce ...

Published in Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society

Migration of epidermal stem cells (EpSCs) into wounds may play an important role in wound healing. Endogenous electric fields (EFs) arise naturally at wounds. Consistent with previous reports, we measured outward electric currents at rat skin wounds using vibrating probes. Topical use of prostaglandin E2 significantly promoted wound healing. Howeve...

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